CHOLINOMIMETIC DRUG RS 86, REM SLEEP, AND DEPRESSION
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چکیده
منابع مشابه
Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, including areas such as the dorsal (DR) and median (MR) raphe nuclei, which are involved in the control of sleep and mood. Major Depression (MD) is a prevalent psychiat...
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In 36 healthy control subjects (21 females, 15 males; age range 18-65 years; mean age 41.8 years, SD 15.6 years), a bedtime dose of 1.5 mg RS 86, an orally acting cholinergic agonist, shortened rapid eye movement (REM) latency, increased REM sleep, and decreased slow-wave sleep. Six of the subjects (greater than 40 years old) even displayed sleep-onset REM periods after the drug. Results of the...
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Copyright: © 2012 Palagini L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Disturbances of sleep are typical of depression and are observed in between 50% and 90% of depressed subjects [1]. Most pati...
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in euthymic patients with primary affective illness. Science 208:200. Sitaram N, Gillin JC, Bunney WE Jr (1984): Cholinergic and catecholaminergic receptor sensitivity in affective illness: Strategy and theory. In Post RM, Ballenger JC (eds), Neurobiology of Mood Disorders. Baltimore: Williams & Wilkins, p 629. Spitzer RL, Endicott J, Robins E (1978): Research Diagnostic Criteria (RDC) for a Se...
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1423 Stage Transition Mechanism for Ultradian Rhythm—Kishi et al neurons themselves. Although further modifications of the original reciprocal interaction model, e.g., the incorporation of selfinhibitory cholinergic autoreceptors and excitatory interactions between cholinergic and non-cholinergic REM-on neurons, have been proposed over the past 30 years with new findings of synaptic details of ...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1985
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(85)91802-1